It would be handy to be able to choose the central key for the various temperaments, but it wouldn't be historically accurate. A baroque instrument would (of course) be in a single temperament (no tuning menus on those babies) so the various temperaments are different approaches to keeping (mostly) thirds in tune in as many keys as possible.
I find that both the "Well" and Werkmeister III are very good from Bb to E, give or take. They tend to get wonky outside those keys but at first no wonkier than equal temperament. If you move the central key around, of course, you'd never have to deal with wonkiness, but that's part of the beauty of a Well temperament; that each key has its own character.